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Researchers have figured out why inflammation damages the heart after a heart attack and have found a way to control the decay with a drug already approved for another condition.
A type of immune cell tries to heal the injured heart but instead triggers inflammation, leading to even more damage, according to research from the Washington University School of Medicine in St. Louis published Thursday in the journal JCI Insight.
About 735,000 Americans have a heart attack each year and about 610,000 die of heart disease, according to the Centers for Disease Control and Prevention. Researchers hope to cut the deaths down by reducing the progression to heart disease after heart attacks.
In the study, mice lived longer if given pirfenidone, a drug already approved to treat an unrelated lung condition. In the heart, they found the drug regulates the specific response of B cell lymphocytes.
Because the drug can have side effects such as nausea and vomiting, the Washington researchers want to improve it. With support from Washington University’s Office of Technology Management, they have launched a startup company focused on developing a new version of pirfenidone.
“If we understand how pirfenidone works to reduce inflammation, we can work to modify the drug or make an even better drug that may be able to help a large number of patients,” author Dr. Douglas L. Mann, director of the university’s Cardiovascular Division and cardiologist-in-chief at Barnes-Jewish Hospital, said in a news release.
Pirfenidone has been treated for idiopathic pulmonary fibrosis, which is when lungs are scarred for no known cause.
Because the drug also has been known for its heart-protective effects after heart attacks in mice, researchers assumed that pirfenidone’s protective action in the heart was why it helps in lung disease.
“That this drug also protects the heart is not new,” said author Dr. Luigi Adamo, a clinical fellow in cardiology. “But in our studies, pirfenidone didn’t physically reduce scar tissue in the heart. The scar tissue is still there, but somehow the heart works better than expected when exposed to this drug. It wasn’t clear why.”
To determine why it happens, they reverse engineered the drug to see how it may be working.
“Since scar tissue was still present, we suspected inflammation was the main culprit in poor heart function after a heart attack,” Adamo said.
When a person survives a heart attack, the body tries to heal the dead muscle by forming scar tissue. However, the scar tissue can further weaken the heart, and more damage occurs when the immune cells try to heal the injured heart and instead increase inflammation.
Most immune heart studies have focused on other types of immune cells, including macrophages, T cell lymphocytes, neutrophils and monocytes. Yet, they found found no differences in the numbers of such immune cells in the injured hearts of mice that received pirfenidone compared with those without.
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But when they measured B cells, they saw a big difference.
“Our results showing B cells driving heart inflammation was quite unexpected,” Adamo said. “We didn’t know that B cells have a role in the type of heart damage we were studying until our data pushed us in that direction. We also found that there isn’t just one type of B cell in the heart, but a whole family of different types that are closely related.”
When the researchers removed these cells, the drug’s benefit also went away. So, they do some good.
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Researchers have figured out why inflammation damages the heart after a heart attack and have found a way to control the decay with a drug already approved for another condition.
A type of immune cell tries to heal the injured heart but instead triggers inflammation, leading to even more damage, according to research from the Washington University School of Medicine in St. Louis published Thursday in the journal JCI Insight.
About 735,000 Americans have a heart attack each year and about 610,000 die of heart disease, according to the Centers for Disease Control and Prevention. Researchers hope to cut the deaths down by reducing the progression to heart disease after heart attacks.
In the study, mice lived longer if given pirfenidone, a drug already approved to treat an unrelated lung condition. In the heart, they found the drug regulates the specific response of B cell lymphocytes.
Because the drug can have side effects such as nausea and vomiting, the Washington researchers want to improve it. With support from Washington University’s Office of Technology Management, they have launched a startup company focused on developing a new version of pirfenidone.
“If we understand how pirfenidone works to reduce inflammation, we can work to modify the drug or make an even better drug that may be able to help a large number of patients,” author Dr. Douglas L. Mann, director of the university’s Cardiovascular Division and cardiologist-in-chief at Barnes-Jewish Hospital, said in a news release.
Pirfenidone has been treated for idiopathic pulmonary fibrosis, which is when lungs are scarred for no known cause.
Because the drug also has been known for its heart-protective effects after heart attacks in mice, researchers assumed that pirfenidone’s protective action in the heart was why it helps in lung disease.
“That this drug also protects the heart is not new,” said author Dr. Luigi Adamo, a clinical fellow in cardiology. “But in our studies, pirfenidone didn’t physically reduce scar tissue in the heart. The scar tissue is still there, but somehow the heart works better than expected when exposed to this drug. It wasn’t clear why.”
To determine why it happens, they reverse engineered the drug to see how it may be working.
“Since scar tissue was still present, we suspected inflammation was the main culprit in poor heart function after a heart attack,” Adamo said.
When a person survives a heart attack, the body tries to heal the dead muscle by forming scar tissue. However, the scar tissue can further weaken the heart, and more damage occurs when the immune cells try to heal the injured heart and instead increase inflammation.
Most immune heart studies have focused on other types of immune cells, including macrophages, T cell lymphocytes, neutrophils and monocytes. Yet, they found found no differences in the numbers of such immune cells in the injured hearts of mice that received pirfenidone compared with those without.
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But when they measured B cells, they saw a big difference.
“Our results showing B cells driving heart inflammation was quite unexpected,” Adamo said. “We didn’t know that B cells have a role in the type of heart damage we were studying until our data pushed us in that direction. We also found that there isn’t just one type of B cell in the heart, but a whole family of different types that are closely related.”
When the researchers removed these cells, the drug’s benefit also went away. So, they do some good.
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Here’s in which factors begin to get extra tricky to unpack. Screenslaver’s modus operandi is to hypnotize men and women by means of their tv sets—he’s a wide metaphor for everybody currently being way too addicted to their a variety of screens, one that just about survives transplantation to the ’60s. Like lots of a villain, he’s fond of monologuing, and his screeds in opposition to Helen cast her and her superhero ilk as a lazy basic safety web for the rest of modern society, draining the citizenry of their cost-free will. He’s the bad male, certainly, but like the offended fanboy villain of the initial Incredibles 2 (who sought to redistribute powers among every person), Screenslaver has a really specific philosophy and ambitions more complex than “world domination.”
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There is so significantly to puzzle over that it helps make Incredibles 2 value a next viewing. Chook has lots to say about this environment of heroes and villains, where the elite reside in community as a individual type of species, each lionized and feared. The diminutive costume designer Edna Manner (voiced by Bird, and as significantly of a highlight in this article as she was in the very first movie) refers to Helen and her loved ones as “gods,” and she’s not completely wrong. But whilst Chicken wishes to engage with the notion of deities dwelling between us, he attracts actual pathos when he reminds viewers of the Parr family’s inherent humanity, all their tremendous-presents apart.
Though the sequel does not have an emotional arc quite as poignant as the initially Incredibles 2 did, its B-plot (which sees Bob participating in stay-at-home father even though Helen goes off to help you save the globe) is even so continually charming. Violet carries on to wrestle with boy drama at university, Sprint is continue to a bundle of unrestrained, teeming electricity, and Jack-Jack starts to manifest his very own powers, which involve bursting into flames and transporting to other dimensions. If The Incredibles 2 was a metaphor for discovering the appropriate equilibrium among perform and loved ones, Incredibles 2 is an outsized satire about how significantly of an unpredictable journey youngster-rearing can be, working day to working day.
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Cialis (tadalafli) relaxes muscles of the blood vessels and increases blood flow to particular areas of the body.
Cialis is used to treat erectlie dysfunction (impotence) and symptoms of benign prostatic hypertrophy (enlarged prostate).
The generic Tadalafil comes under a variety of different names including:
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Do not take Cialis if you are also using a nitrate drug for chest pain or heart problems, including nitroglycerin, isosorbide dinitrate, isosorbide mononitrate, and some recreational drugs such as “poppers”. Taking tadalafli with a nitrate medicine can cause a sudden and serious decrease in blood pressure.
Some medicines can cause unwanted or dangerous effects when used with Cialis. Tell your doctor about all your current medicines, especially riociguat (Adempas).
Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.
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Cialis is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
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Drinking alcohol with this medicine can cause side effects.
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Get emergency medical help if you have signs of an allergic reaction to Cialis: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
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